Version 5.4
Homo sapiens Gene: SOX5
Summary
InnateDB Gene IDBG-23504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX5
Gene Name SRY (sex determining region Y)-box 5
Synonyms L-SOX5; L-SOX5B; L-SOX5F
Species Homo sapiens
Ensembl Gene ENSG00000134532
Encoded Proteins
IDBP-23508
SRY (sex determining region Y)-box 5
IDBP-106004
SRY (sex determining region Y)-box 5
IDBP-238377
SRY (sex determining region Y)-box 5
IDBP-362391
SRY (sex determining region Y)-box 5
IDBP-369739
SRY (sex determining region Y)-box 5
IDBP-597322
SRY (sex determining region Y)-box 5
IDBP-586399
SRY (sex determining region Y)-box 5
IDBP-590434
SRY (sex determining region Y)-box 5
IDBP-601444
SRY (sex determining region Y)-box 5
IDBP-601940
SRY (sex determining region Y)-box 5
IDBP-593896
SRY (sex determining region Y)-box 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:23529500-23951032
Strand Reverse strand
Band p12.1
Transcripts
ENST00000381381 ENSP00000370788
ENST00000367206 ENSP00000356174
ENST00000396007 ENSP00000379328
ENST00000441133 ENSP00000393240
ENST00000451604 ENSP00000398273
ENST00000546136 ENSP00000437487
ENST00000537393 ENSP00000439832
ENST00000541536 ENSP00000441973
ENST00000545921 ENSP00000443520
ENST00000535530
ENST00000542241
ENST00000536629
ENST00000536911
ENST00000541847 ENSP00000442119
ENST00000538083 ENSP00000441579
ENST00000536850
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 18 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006366 transcription from RNA polymerase II promoter
GO:0021953 central nervous system neuron differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048709 oligodendrocyte differentiation
GO:0051216 cartilage development
GO:0060164 regulation of timing of neuron differentiation
GO:0061036 positive regulation of cartilage development
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041540
View Gene Order
ENSBTAG00000022360
Not yet available
Cross-References
SwissProt P35711
TrEMBL F5GWL1 T2CYZ2
UniProt Splice Variant
Entrez Gene 6660
UniGene Hs.434948 Hs.657542
RefSeq NM_152989 XM_006719149 XM_006719150 NM_001261414 NM_001261415 NM_006940 NM_178010
HUGO HGNC:11201
OMIM 604975
CCDS CCDS44844 CCDS41761 CCDS58216 CCDS58217 CCDS8699
HPRD 18086
IMGT
EMBL AB081588 AB081589 AB081590 AB081591 AC087244 AC087260 AC087319 AC092864 AK074317 AK098610 AK303970 BC029220 BC035227 BC047665 BC060773 JX570584 S83308 X65662
GenPept AAB49537 AAH29220 AAH35227 AAH47665 AAH60773 AGV38565 BAB85048 BAC05353 BAC16233 BAC16234 BAC16235 BAC16236 BAH14086 CAA46613
RNA Seq Atlas 6660

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca