Version 5.4
Homo sapiens Protein: SKA1
Summary
InnateDB Protein IDBP-369770.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKA1
Protein Name spindle and kinetochore associated complex subunit 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397222
InnateDB Gene IDBG-3435 (SKA1)
Protein Structure
UniProt Annotation
Function Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. {ECO:0000269PubMed:17093495, ECO:0000269PubMed:19289083}.
Subcellular Localization Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid- anaphase and then vanishes in telophase.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0051301 cell division
Cellular Component
GO:0000940 condensed chromosome outer kinetochore
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR009829 Protein of unknown function DUF1395
PFAM PF07160
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BD8
PhosphoSite PhosphoSite-Q96BD8
TrEMBL K7EP61
UniProt Splice Variant
Entrez Gene 220134
UniGene Hs.134726
RefSeq
HUGO HGNC:28109
OMIM
CCDS
HPRD 12689
IMGT
EMBL AC105227 AK303464 AK313968 BC015706 CH471096
GenPept AAH15706 BAG36683 BAG64506 EAW62971

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca