InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL21

Summary

InnateDB Protein

IDBP-36979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL21

Protein Name

interleukin 21

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264497

InnateDB Gene

IDBG-36977 (IL21)

Protein Structure

UniProt Annotation

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269PubMed:11081504, ECO:0000269PubMed:15178704}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11081504}.

Disease Associations

Tissue Specificity

Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269PubMed:11081504}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	6 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005134	interleukin-2 receptor binding

Biological Process

GO:0002729	positive regulation of natural killer cell cytokine production
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0030890	positive regulation of B cell proliferation
GO:0032733	positive regulation of interleukin-10 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032825	positive regulation of natural killer cell differentiation
GO:0034105	positive regulation of tissue remodeling
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048469	cell maturation
GO:0050729	positive regulation of inflammatory response