InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL21

Summary

InnateDB Gene

IDBG-36977.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL21

Gene Name

interleukin 21

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000138684

Encoded Proteins

IDBP-36979

interleukin 21

IDBP-812161

interleukin 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20817119

IL21 is a cytokine that has broad effects on both innate and adaptive immune responses.

InnateDB Annotation from Orthologs

Summary

PMID 23453633

[Mus musculus] IL21 induces apoptosis of conventional dendritic cells.

Entrez Gene

Summary

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:122612628-122621069

Strand

Reverse strand

Band

q27

Transcripts

ENST00000264497	ENSP00000264497
ENST00000611104	ENSP00000477555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	6 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005134	interleukin-2 receptor binding

Biological Process

GO:0002729	positive regulation of natural killer cell cytokine production
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0030890	positive regulation of B cell proliferation
GO:0032733	positive regulation of interleukin-10 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032825	positive regulation of natural killer cell differentiation
GO:0034105	positive regulation of tissue remodeling
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048469	cell maturation
GO:0050729	positive regulation of inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027718

View Gene Order

ENSBTAG00000012368

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q9HBE4

TrEMBL

UniProt Splice Variant

Entrez Gene

59067

UniGene

RefSeq

NM_001207006 NM_021803

HUGO

HGNC:6005

OMIM

605384

CCDS

CCDS3727 CCDS75189

HPRD

IMGT

EMBL

AC053545 AF254069 AY763518 BC066258 BC066259 BC066260 BC066261 BC066262 BC069124 DQ645417

GenPept

AAG29348 AAH66258 AAH66259 AAH66260 AAH66261 AAH66262 AAH69124 AAU88182 ABG36529

RNA Seq Atlas

59067