InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPN1

Summary

InnateDB Protein

IDBP-370296.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPN1

Protein Name

GPN-loop GTPase 1

Synonyms

ATPBD1A; MBDIN; NTPBP; RPAP4; XAB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000398115

InnateDB Gene

IDBG-40039 (GPN1)

Protein Structure

UniProt Annotation

Function

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA. {ECO:0000269PubMed:17643375}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11058119}.

Disease Associations

Tissue Specificity

Expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004130 Uncharacterised protein family, ATP binding
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03029

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HCN4