InnateDB Protein
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IDBP-370611.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARPP21
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Protein Name
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cAMP-regulated phosphoprotein, 21kDa
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Synonyms
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ARPP-21; R3HDM3; RCS; TARPP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000405276
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InnateDB Gene
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IDBG-24449 (ARPP21)
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Protein Structure
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Function |
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). {ECO:0000269PubMed:15096520, ECO:0000269PubMed:8120638}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001374
Single-stranded nucleic acid binding R3H
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PFAM |
PF01424
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PRINTS |
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PIRSF |
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SMART |
SM00393
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBL0
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PhosphoSite |
PhosphoSite-Q9UBL0
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TrEMBL |
C9JTX6
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UniProt Splice Variant |
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Entrez Gene |
10777
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UniGene |
Hs.602539
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RefSeq |
NP_001254546
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HUGO |
HGNC:16968
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OMIM |
605488
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CCDS |
CCDS58824
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HPRD |
09265
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IMGT |
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EMBL |
AC016943
AC104308
AC133143
AF112220
AK294484
AL133109
BC017805
BC031106
BC036399
BC041385
BC051828
BC066651
CH471055
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GenPept |
AAF17207
AAH17805
AAH31106
AAH36399
AAH41385
AAH51828
AAH66651
BAG57707
CAB61414
EAW64471
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