Version 5.4
Homo sapiens Protein: ARPP21
Summary
InnateDB Protein IDBP-370648.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPP21
Protein Name cAMP-regulated phosphoprotein, 21kDa
Synonyms ARPP-21; R3HDM3; RCS; TARPP;
Species Homo sapiens
Ensembl Protein ENSP00000412326
InnateDB Gene IDBG-24449 (ARPP21)
Protein Structure
UniProt Annotation
Function Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). {ECO:0000269PubMed:15096520, ECO:0000269PubMed:8120638}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0005516 calmodulin binding
Biological Process
GO:0008150 biological_process
GO:0034605 cellular response to heat
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001374 Single-stranded nucleic acid binding R3H
PFAM PF01424
PRINTS
PIRSF
SMART SM00393
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBL0
PhosphoSite PhosphoSite-Q9UBL0
TrEMBL C9JTX6
UniProt Splice Variant
Entrez Gene 10777
UniGene Hs.602539
RefSeq NP_001254548
HUGO HGNC:16968
OMIM 605488
CCDS CCDS58823
HPRD 09265
IMGT
EMBL AC016943 AC104308 AC133143 AF112220 AK294484 AL133109 BC017805 BC031106 BC036399 BC041385 BC051828 BC066651 CH471055
GenPept AAF17207 AAH17805 AAH31106 AAH36399 AAH41385 AAH51828 AAH66651 BAG57707 CAB61414 EAW64471

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca