InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLB1

Summary

InnateDB Protein

IDBP-370795.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLB1

Protein Name

phospholipase B1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000416440

InnateDB Gene

IDBG-41280 (PLB1)

Protein Structure

UniProt Annotation

Function

Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Present in the intestinal brush border membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the epidermis (at protein level). {ECO:0000269PubMed:12150957}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0004623	phospholipase A2 activity
GO:0016788	hydrolase activity, acting on ester bonds

Biological Process

GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0007603	phototransduction, visible light
GO:0016042	lipid catabolic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process