InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNA4

Summary

InnateDB Protein

IDBP-37085.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNA4

Protein Name

potassium voltage-gated channel, shaker-related subfamily, member 4

Synonyms

HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; PCN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000328511

InnateDB Gene

IDBG-37083 (KCNA4)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030955	potassium ion binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003972 Potassium channel, voltage dependent, Kv1
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR012897 Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain
IPR013099 Two pore domain potassium channel domain
IPR020467 Potassium channel, voltage dependent, Kv1.4

PFAM

PF02214
PF00520
PF07941
PF07885

PRINTS

PR00169
PR01491
PR01496
PR01511

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt