InnateDB Protein
|
IDBP-371229.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
FBLIM1
|
Protein Name
|
filamin binding LIM protein 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000416387
|
InnateDB Gene
|
IDBG-91122 (FBLIM1)
|
Protein Structure
|
|
Function |
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269PubMed:12496242, ECO:0000269PubMed:12679033, ECO:0000269PubMed:18829455, ECO:0000269PubMed:19074766}.
|
Subcellular Localization |
Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers.
|
Disease Associations |
|
Tissue Specificity |
Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269PubMed:12496242}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001781
Zinc finger, LIM-type
|
PFAM |
PF00412
|
PRINTS |
|
PIRSF |
|
SMART |
SM00132
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8WUP2
|
PhosphoSite |
PhosphoSite-Q8WUP2
|
TrEMBL |
E7EPI5
|
UniProt Splice Variant |
|
Entrez Gene |
54751
|
UniGene |
Hs.739205
|
RefSeq |
NP_001019386
|
HUGO |
HGNC:24686
|
OMIM |
607747
|
CCDS |
CCDS44064
|
HPRD |
09669
|
IMGT |
|
EMBL |
AF459643
AK027444
AK055259
AL133035
AL450998
AY180161
BC019895
|
GenPept |
AAH19895
AAO15549
AAO49012
BAB55115
BAG51492
CAB61365
CAH70853
CAH70854
|
|
|