InnateDB Protein
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IDBP-37138.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TFEC
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Protein Name
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transcription factor EC
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Synonyms
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bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L; TFECL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000265440
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InnateDB Gene
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IDBG-37136 (TFEC)
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Protein Structure
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Function |
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269PubMed:11467950, ECO:0000269PubMed:9256061}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:11467950}.
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Disease Associations |
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Tissue Specificity |
Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon. {ECO:0000269PubMed:11467950, ECO:0000269PubMed:15118077}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802
Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
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PFAM |
PF00010
PF11851
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
O14948
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PhosphoSite |
PhosphoSite-O14948
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TrEMBL |
Q75MG2
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UniProt Splice Variant |
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Entrez Gene |
22797
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UniGene |
Hs.734939
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RefSeq |
NP_036384
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HUGO |
HGNC:11754
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OMIM |
604732
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CCDS |
CCDS5762
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HPRD |
05294
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IMGT |
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EMBL |
AC073141
AC096551
AJ608795
AK313546
BC029891
CH236947
CH471070
CR933605
D43945
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GenPept |
AAH29891
AAS02009
AAS07449
BAA21908
BAG36322
CAE77680
CAI45926
EAL24366
EAW83491
EAW83492
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