Version 5.4
Homo sapiens Gene: TFEC
Summary
InnateDB Gene IDBG-37136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFEC
Gene Name transcription factor EC
Synonyms bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L; TFECL
Species Homo sapiens
Ensembl Gene ENSG00000105967
Encoded Proteins
IDBP-37138
transcription factor EC
IDBP-37140
transcription factor EC
IDBP-243522
transcription factor EC
IDBP-385530
transcription factor EC
IDBP-477119
transcription factor EC
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:115935148-116159896
Strand Reverse strand
Band q31.2
Transcripts
ENST00000265440 ENSP00000265440
ENST00000320239 ENSP00000318676
ENST00000393485 ENSP00000377125
ENST00000457268 ENSP00000387650
ENST00000462828
ENST00000484212 ENSP00000417432
ENST00000497829
ENST00000474337
ENST00000465322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034605 cellular response to heat
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029553
View Gene Order
ENSBTAG00000014228
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt O14948
TrEMBL
UniProt Splice Variant
Entrez Gene 22797
UniGene Hs.125962 Hs.722611 Hs.734939
RefSeq NM_001018058 NM_001244583 NM_012252
HUGO HGNC:11754
OMIM 604732
CCDS CCDS34738 CCDS5762 CCDS59076
HPRD 05294
IMGT
EMBL AJ608795 AK313546 BC029891 CH236947 CH471070 CR933605 D43945
GenPept AAH29891 BAA21908 BAG36322 CAE77680 CAI45926 EAL24366 EAW83491 EAW83492
RNA Seq Atlas 22797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca