Version 5.4
Homo sapiens Protein: TFEC
Summary
InnateDB Protein IDBP-37140.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFEC
Protein Name transcription factor EC
Synonyms bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L; TFECL;
Species Homo sapiens
Ensembl Protein ENSP00000318676
InnateDB Gene IDBG-37136 (TFEC)
Protein Structure
UniProt Annotation
Function Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269PubMed:11467950, ECO:0000269PubMed:9256061}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:11467950}.
Disease Associations
Tissue Specificity Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon. {ECO:0000269PubMed:11467950, ECO:0000269PubMed:15118077}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802 Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
PFAM PF00010
PF11851
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14948
PhosphoSite PhosphoSite-O14948
TrEMBL Q75KY0
UniProt Splice Variant
Entrez Gene 22797
UniGene Hs.734939
RefSeq NP_001018068
HUGO HGNC:11754
OMIM 604732
CCDS CCDS34738
HPRD 05294
IMGT
EMBL AC096551 AJ608795 AK313546 BC029891 CH236947 CH471070 CR933605 D43945
GenPept AAH29891 AAS02009 BAA21908 BAG36322 CAE77680 CAI45926 EAL24366 EAW83491 EAW83492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca