InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GFM2

Summary

InnateDB Protein

IDBP-371688.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFM2

Protein Name

G elongation factor, mitochondrial 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000405808

InnateDB Gene

IDBG-28574 (GFM2)

Protein Structure

UniProt Annotation

Function

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. {ECO:0000255HAMAP-Rule:MF_03059, ECO:0000269PubMed:19716793}.

Subcellular Localization

Mitochondrion {ECO:0000255HAMAP- Rule:MF_03059}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11735030}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0032543	mitochondrial translation
GO:0032790	ribosome disassembly

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR009000 Translation protein, beta-barrel domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q969S9