Version 5.4
Homo sapiens Gene: GFM2
Summary
InnateDB Gene IDBG-28574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFM2
Gene Name G elongation factor, mitochondrial 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164347
Encoded Proteins
IDBP-28580
G elongation factor, mitochondrial 2
IDBP-28582
G elongation factor, mitochondrial 2
IDBP-371688
G elongation factor, mitochondrial 2
IDBP-481098
G elongation factor, mitochondrial 2
IDBP-483995
G elongation factor, mitochondrial 2
IDBP-480508
G elongation factor, mitochondrial 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at least three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:74721204-74767371
Strand Reverse strand
Band q13.3
Transcripts
ENST00000296805 ENSP00000296805
ENST00000345239 ENSP00000296804
ENST00000427854 ENSP00000405808
ENST00000509430 ENSP00000427004
ENST00000515125
ENST00000514734
ENST00000506263
ENST00000513331
ENST00000509097 ENSP00000421717
ENST00000506778 ENSP00000424877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0032543 mitochondrial translation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021666
View Gene Order
ENSBTAG00000015519
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267602
Mitochondrial translation termination pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.277154
RefSeq NM_001281302 NM_032380 NM_170681 NM_170691
HUGO
OMIM
CCDS CCDS4023 CCDS4024 CCDS47232
HPRD 09413
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca