InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKL2

Summary

InnateDB Protein

IDBP-371715.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKL2

Protein Name

cyclin-dependent kinase-like 2 (CDC2-related kinase)

Synonyms

KKIAMRE; P56;

Species

Homo sapiens

Ensembl Protein

ENSP00000412365

InnateDB Gene

IDBG-24650 (CDKL2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9000130}. Nucleus {ECO:0000269PubMed:9000130}.

Disease Associations

Tissue Specificity

Expressed in testis and kidney, and at lower level in brain and lung. {ECO:0000269PubMed:9000130}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007548	sex differentiation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt