InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CISH

Summary

InnateDB Protein

IDBP-37177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CISH

Protein Name

cytokine inducible SH2-containing protein

Synonyms

BACTS2; CIS; CIS-1; G18; SOCS;

Species

Homo sapiens

Ensembl Protein

ENSP00000294173

InnateDB Gene

IDBG-37175 (CISH)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269PubMed:11032736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	29 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway