InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CISH

Summary

InnateDB Gene

IDBG-37175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CISH

Gene Name

cytokine inducible SH2-containing protein

Synonyms

BACTS2; CIS; CIS-1; G18; SOCS

Species

Homo sapiens

Ensembl Gene

ENSG00000114737

Encoded Proteins

IDBP-37177

cytokine inducible SH2-containing protein

IDBP-378595

cytokine inducible SH2-containing protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19592657

CISH is a negative regulator for inflammatory cytokine signalling that enhances NFKBIA (IKappaB-alpha) degradation and regulation and activates NF-kappaB in cholangiocytes in response to LPS stimulation.

PMID 19592657

CISH expression in cholangiocytes is conferred by hsa-mir-98 and hsa-let-7e in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response.

Entrez Gene

Summary

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50606490-50611831

Strand

Reverse strand

Band

p21.2

Transcripts

ENST00000348721	ENSP00000294173
ENST00000443053	ENSP00000409346
ENST00000491847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	29 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway