InnateDB Protein
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IDBP-37188.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CALCOCO1
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Protein Name
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calcium binding and coiled-coil domain 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262059
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InnateDB Gene
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IDBG-37186 (CALCOCO1)
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Protein Structure
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Function |
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). {ECO:0000250}.Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269Ref.1}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR012852
Coiled-coil transcriptional coactivator-like
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PFAM |
PF07888
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P1Z2
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PhosphoSite |
PhosphoSite-Q9P1Z2
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TrEMBL |
F8W0X2
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UniProt Splice Variant |
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Entrez Gene |
57658
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UniGene |
Hs.156667
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RefSeq |
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HUGO |
HGNC:29306
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OMIM |
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CCDS |
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HPRD |
13868
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IMGT |
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EMBL |
AB040969
AC076968
AF370415
AK027881
AK122773
AL136895
AY211909
AY358397
AY563137
BC003177
CH471054
CR533567
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GenPept |
AAH03177
AAO65163
AAQ15251
AAQ88763
AAT68474
BAA96060
BAB55428
BAG53720
CAB66829
CAG38598
EAW96728
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