Version 5.4
Homo sapiens Protein: TES
Summary
InnateDB Protein IDBP-37198.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TES
Protein Name testis derived transcript (3 LIM domains)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350937
InnateDB Gene IDBG-37196 (TES)
Protein Structure
UniProt Annotation
Function Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:0000269PubMed:11420696, ECO:0000269PubMed:12571287, ECO:0000269PubMed:12695497}.
Subcellular Localization Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:11420696}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
IPR010442 PET domain
PFAM PF00412
PF06297
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UGI8
PhosphoSite PhosphoSite-Q9UGI8
TrEMBL Q9Y423
UniProt Splice Variant
Entrez Gene 26136
UniGene Hs.630572
RefSeq NP_056456
HUGO HGNC:14620
OMIM 606085
CCDS CCDS5763
HPRD 05833
IMGT
EMBL AC073130 AF245356 AF245357 AF260225 AJ250865 AK021575 AK291802 AK300546 AL050162 BC001451 CH236947 CH471070
GenPept AAG17612 AAG17613 AAG17635 AAG17636 AAH01451 AAQ93367 BAB13846 BAF84491 BAH13301 CAB43302 CAB65119 EAL24364 EAL24365 EAW83497

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca