Version 5.4
Homo sapiens Gene: TES
Summary
InnateDB Gene IDBG-37196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TES
Gene Name testis derived transcript (3 LIM domains)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135269
Encoded Proteins
IDBP-37198
testis derived transcript (3 LIM domains)
IDBP-243528
testis derived transcript (3 LIM domains)
IDBP-243530
testis derived transcript (3 LIM domains)
IDBP-385540
testis derived transcript (3 LIM domains)
IDBP-477826
testis derived transcript (3 LIM domains)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:116210493-116258783
Strand Forward strand
Band q31.2
Transcripts
ENST00000358204 ENSP00000350937
ENST00000393484 ENSP00000377124
ENST00000393481 ENSP00000377121
ENST00000455989 ENSP00000413002
ENST00000461440
ENST00000492891 ENSP00000420220
ENST00000496871
ENST00000485009
ENST00000494384
ENST00000496912
ENST00000463746
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029552
View Gene Order
ENSBTAG00000021204
Not yet available
Cross-References
SwissProt
TrEMBL F8W7T0
UniProt Splice Variant
Entrez Gene 26136
UniGene Hs.592286 Hs.607407 Hs.630572
RefSeq NM_015641 NM_152829 XM_005250258
HUGO HGNC:14620
OMIM 606085
CCDS CCDS5763 CCDS5764
HPRD 05833
IMGT
EMBL AC073130
GenPept
RNA Seq Atlas 26136

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca