InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULF1

Summary

InnateDB Protein

IDBP-372235.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULF1

Protein Name

sulfatase 1

Synonyms

HSULF-1; SULF-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000390315

InnateDB Gene

IDBG-24665 (SULF1)

Protein Structure

UniProt Annotation

Function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004065	arylsulfatase activity
GO:0005509	calcium ion binding
GO:0008449	N-acetylglucosamine-6-sulfatase activity
GO:0008484	sulfuric ester hydrolase activity

Biological Process

GO:0001822	kidney development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0002063	chondrocyte development
GO:0003094	glomerular filtration
GO:0006915	apoptotic process
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014846	esophagus smooth muscle contraction
GO:0016525	negative regulation of angiogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030201	heparan sulfate proteoglycan metabolic process
GO:0030336	negative regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0032836	glomerular basement membrane development
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048706	embryonic skeletal system development
GO:0051216	cartilage development
GO:0060348	bone development
GO:0060384	innervation
GO:0060686	negative regulation of prostatic bud formation

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000917 Sulfatase
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR014615 Extracellular sulfatase
IPR017850 Alkaline-phosphatase-like, core domain
IPR024609 Extracellular sulfatase, C-terminal

PFAM

PF00884
PF01663
PF12548

PRINTS

PIRSF

PIRSF036665

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IWU6