Version 5.4
Homo sapiens Gene: SULF1
Summary
InnateDB Gene IDBG-24665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULF1
Gene Name sulfatase 1
Synonyms HSULF-1; SULF-1
Species Homo sapiens
Ensembl Gene ENSG00000137573
Encoded Proteins
IDBP-24667
sulfatase 1
IDBP-293452
sulfatase 1
IDBP-372232
sulfatase 1
IDBP-372235
sulfatase 1
IDBP-595756
sulfatase 1
IDBP-589821
sulfatase 1
IDBP-593692
sulfatase 1
IDBP-583209
sulfatase 1
IDBP-583237
sulfatase 1
IDBP-585021
sulfatase 1
IDBP-810609
sulfatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:69466624-69660915
Strand Forward strand
Band q13.2
Transcripts
ENST00000260128 ENSP00000260128
ENST00000402687 ENSP00000385704
ENST00000458141 ENSP00000403040
ENST00000419716 ENSP00000390315
ENST00000521946
ENST00000525061 ENSP00000436608
ENST00000528286
ENST00000529134 ENSP00000432178
ENST00000529041
ENST00000534179 ENSP00000431308
ENST00000525112
ENST00000528783 ENSP00000436949
ENST00000525999 ENSP00000431753
ENST00000531064
ENST00000526808
ENST00000534088
ENST00000528146
ENST00000524731
ENST00000531512 ENSP00000434128
ENST00000530674
ENST00000532015
ENST00000526654
ENST00000616868 ENSP00000480454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0005509 calcium ion binding
GO:0008449 N-acetylglucosamine-6-sulfatase activity
GO:0008484 sulfuric ester hydrolase activity
Biological Process
GO:0001822 kidney development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002063 chondrocyte development
GO:0003094 glomerular filtration
GO:0006915 apoptotic process
GO:0008152 metabolic process
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0014846 esophagus smooth muscle contraction
GO:0016525 negative regulation of angiogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0030336 negative regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0032836 glomerular basement membrane development
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048706 embryonic skeletal system development
GO:0051216 cartilage development
GO:0060348 bone development
GO:0060384 innervation
GO:0060686 negative regulation of prostatic bud formation
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016918
View Gene Order
ENSBTAG00000004720
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.409602 Hs.617218 Hs.710666
RefSeq NM_001128204 NM_001128205 NM_001128206 NM_015170 XM_006716438 XM_006716442
HUGO
OMIM
CCDS CCDS6204
HPRD 15450
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca