InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOA2

Summary

InnateDB Protein

IDBP-372282.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA2

Protein Name

nuclear receptor coactivator 2

Synonyms

bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000399968

InnateDB Gene

IDBG-24827 (NCOA2)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. {ECO:0000269PubMed:23508108, ECO:0000269PubMed:9430642}.

Subcellular Localization

Nucleus.

Disease Associations

Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N- terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	78 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0035257	nuclear hormone receptor binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010906	regulation of glucose metabolic process
GO:0016573	histone acetylation
GO:0030521	androgen receptor signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR014935 Steroid receptor coactivator
IPR017426 Nuclear receptor coactivator

PFAM