Version 5.4
Homo sapiens Gene: NCOA2
Summary
InnateDB Gene IDBG-24827.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA2
Gene Name nuclear receptor coactivator 2
Synonyms bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2
Species Homo sapiens
Ensembl Gene ENSG00000140396
Encoded Proteins
IDBP-372282
nuclear receptor coactivator 2
IDBP-474909
nuclear receptor coactivator 2
IDBP-478639
nuclear receptor coactivator 2
IDBP-479845
nuclear receptor coactivator 2
IDBP-475975
nuclear receptor coactivator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene\'s transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70109762-70403805
Strand Reverse strand
Band q13.3
Transcripts
ENST00000452400 ENSP00000399968
ENST00000518287 ENSP00000430148
ENST00000518363 ENSP00000429132
ENST00000521239
ENST00000522054
ENST00000524223
ENST00000519724 ENSP00000430348
ENST00000520416 ENSP00000430850
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 78 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 thyroid hormone receptor coactivator activity
GO:0035257 nuclear hormone receptor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0010906 regulation of glucose metabolic process
GO:0016573 histone acetylation
GO:0030521 androgen receptor signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005886
View Gene Order
ENSBTAG00000020312
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11048
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_13812
Endogenous sterols pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_267716
Orphan transporters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_71
Gene Expression pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
PID NCI
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ar_pathway
Coregulation of Androgen receptor activity
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
reg_gr_pathway
Glucocorticoid receptor regulatory network
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10499
UniGene Hs.446678 Hs.595378 Hs.596184 Hs.618025 Hs.727231
RefSeq NM_006540 XM_005251128 XM_005251129 XM_005251130 XM_005251131 XM_005251132
HUGO HGNC:7669
OMIM 601993
CCDS CCDS47872
HPRD 09066
IMGT
EMBL
GenPept
RNA Seq Atlas 10499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca