InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP8

Summary

InnateDB Protein

IDBP-372485.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP8

Protein Name

ubiquitin specific peptidase 8

Synonyms

HumORF8; SPG59; UBPY;

Species

Homo sapiens

Ensembl Protein

ENSP00000412682

InnateDB Gene

IDBG-11726 (USP8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007032	endosome organization
GO:0008283	cell proliferation
GO:0016579	protein deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody

Protein Structure and Domains

PDB ID

InterPro

IPR001202 WW domain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001763 Rhodanese-like domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00397
PF00443
PF00581

PRINTS

PIRSF

SMART

SM00456
SM00450

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P40818