InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAV2

Summary

InnateDB Protein

IDBP-37252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAV2

Protein Name

caveolin 2

Synonyms

CAV;

Species

Homo sapiens

Ensembl Protein

ENSP00000222693

InnateDB Gene

IDBG-37250 (CAV2)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. {ECO:0000269PubMed:9361015}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031748	D1 dopamine receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006906	vesicle fusion
GO:0007005	mitochondrion organization
GO:0007029	endoplasmic reticulum organization
GO:0007088	regulation of mitosis
GO:0008285	negative regulation of cell proliferation
GO:0016050	vesicle organization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048278	vesicle docking
GO:0048741	skeletal muscle fiber development
GO:0051259	protein oligomerization
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0070836	caveola assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm