Version 5.4
Homo sapiens Gene: CAV2
Summary
InnateDB Gene IDBG-37250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAV2
Gene Name caveolin 2
Synonyms CAV
Species Homo sapiens
Ensembl Gene ENSG00000105971
Encoded Proteins
IDBP-37252
caveolin 2
IDBP-37254
caveolin 2
IDBP-243538
caveolin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:116287380-116508541
Strand Forward strand
Band q31.2
Transcripts
ENST00000222693 ENSP00000222693
ENST00000343213 ENSP00000345679
ENST00000393480 ENSP00000377120
ENST00000490906
ENST00000460222
ENST00000467035
ENST00000477018
ENST00000484871
ENST00000485561
ENST00000472470
ENST00000498493
ENST00000462876
ENST00000478226
ENST00000465451
ENST00000495841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031748 D1 dopamine receptor binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006906 vesicle fusion
GO:0007005 mitochondrion organization
GO:0007029 endoplasmic reticulum organization
GO:0007088 regulation of mitosis
GO:0008285 negative regulation of cell proliferation
GO:0016050 vesicle organization
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048278 vesicle docking
GO:0048741 skeletal muscle fiber development
GO:0051259 protein oligomerization
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0070836 caveola assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0002080 acrosomal membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0030133 transport vesicle
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000058
View Gene Order
ENSBTAG00000045584
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04510
Focal adhesion pathway
hsa04144
Endocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
Cross-References
SwissProt P51636
TrEMBL E9PCT3 Q53X57 Q712N7
UniProt Splice Variant
Entrez Gene 858
UniGene Hs.212332 Hs.603096 Hs.671556 Hs.707759 Hs.737623
RefSeq NM_001206747 NM_001206748 NM_001233 NM_198212
HUGO HGNC:1528
OMIM 601048
CCDS CCDS5765 CCDS5766
HPRD
IMGT
EMBL AB451285 AB451417 AC002066 AC006159 AC073130 AC074021 AF035752 AJ011300 AJ133269 AJ242718 AK310786 AK311964 BC005256 BT007051 CH236947 CH471070 CR407685
GenPept AAB88492 AAH05256 AAP35700 BAG34904 BAG70099 BAG70231 CAB36907 CAB63653 CAB65090 CAG28613 EAL24361 EAL24362 EAW83501 EAW83502
RNA Seq Atlas 858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca