Version 5.4
Homo sapiens Protein: UBE2W
Summary
InnateDB Protein IDBP-372576.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2W
Protein Name ubiquitin-conjugating enzyme E2W (putative)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397453
InnateDB Gene IDBG-25727 (UBE2W)
Protein Structure
UniProt Annotation
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. {ECO:0000269PubMed:19111657, ECO:0000269PubMed:20061386, ECO:0000269PubMed:21229326, ECO:0000269PubMed:23560854, ECO:0000269PubMed:23696636}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16368532}. Note=In the nucleus, colocalizes with FANCL.
Disease Associations
Tissue Specificity Widely expressed, with highest expression in brain, liver, pancreas and heart. {ECO:0000269PubMed:16368532}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0008152 metabolic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q96B02
TrEMBL X6REH9
UniProt Splice Variant
Entrez Gene 55284
UniGene Hs.730853
RefSeq NP_001001481
HUGO HGNC:25616
OMIM 614277
CCDS CCDS47875
HPRD 07724
IMGT
EMBL AC022826 AC022868 CH471068
GenPept EAW87012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca