InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2W

Summary

InnateDB Gene

IDBG-25727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2W

Gene Name

ubiquitin-conjugating enzyme E2W (putative)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000104343

Encoded Proteins

IDBP-372576

ubiquitin-conjugating enzyme E2W (putative)

IDBP-372577

ubiquitin-conjugating enzyme E2W (putative)

IDBP-480978

ubiquitin-conjugating enzyme E2W (putative)

IDBP-475128

ubiquitin-conjugating enzyme E2W (putative)

IDBP-477724

ubiquitin-conjugating enzyme E2W (putative)

IDBP-479612

ubiquitin-conjugating enzyme E2W (putative)

IDBP-808024

ubiquitin-conjugating enzyme E2W (putative)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26101372

TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis

Entrez Gene

Summary

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:73780097-73878910

Strand

Reverse strand

Band

q21.11

Transcripts

ENST00000419880	ENSP00000397453
ENST00000422906	ENSP00000414771
ENST00000523278	ENSP00000428835
ENST00000517608	ENSP00000428813
ENST00000519277	ENSP00000430254
ENST00000519255	ENSP00000429136
ENST00000602593	ENSP00000473561

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.

Experimentally validated
Total	75 [view]
Protein-Protein	74 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006281	DNA repair
GO:0006513	protein monoubiquitination
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0008152	metabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0070979	protein K11-linked ubiquitination
GO:0071218	cellular response to misfolded protein

Cellular Component

GO:0005634

nucleus

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.128841 Hs.624628 Hs.730853

RefSeq

NM_001001481 NM_001271015 NM_018299

HUGO

OMIM

CCDS

CCDS47874 CCDS47875

HPRD

07724

IMGT

EMBL

GenPept

RNA Seq Atlas