Version 5.4
Homo sapiens Protein: DMXL2
Summary
InnateDB Protein IDBP-372809.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMXL2
Protein Name Dmx-like 2
Synonyms RC3;
Species Homo sapiens
Ensembl Protein ENSP00000400855
InnateDB Gene IDBG-12130 (DMXL2)
Protein Structure
UniProt Annotation
Function May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. {ECO:0000269PubMed:11809763}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269PubMed:11809763}; Peripheral membrane protein {ECO:0000269PubMed:11809763}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR022033 RAVE complex protein Rav1 C-terminal
PFAM PF00400
PF12234
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDJ6
PhosphoSite PhosphoSite-Q8TDJ6
TrEMBL
UniProt Splice Variant
Entrez Gene 23312
UniGene Hs.725363
RefSeq NP_001167588
HUGO HGNC:2938
OMIM 612186
CCDS CCDS53945
HPRD 10188
IMGT
EMBL AB020663 AC020892 AC066613 AF389880 BC140781 BC144539
GenPept AAI40782 AAI44540 AAL93215 BAA74879

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca