Version 5.4
Homo sapiens Protein: TMOD2
Summary
InnateDB Protein IDBP-372859.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMOD2
Protein Name tropomodulin 2 (neuronal)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000404590
InnateDB Gene IDBG-12237 (TMOD2)
Protein Structure
UniProt Annotation
Function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Neuronal-tissue specific. {ECO:0000269PubMed:10662549}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 7 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005523 tropomyosin binding
Biological Process
GO:0007399 nervous system development
GO:0051694 pointed-end actin filament capping
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR004934 Tropomodulin
PFAM PF03250
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZR1
PhosphoSite PhosphoSite-Q9NZR1
TrEMBL
UniProt Splice Variant
Entrez Gene 29767
UniGene Hs.722897
RefSeq NP_001136357
HUGO HGNC:11872
OMIM 602928
CCDS CCDS45260
HPRD 04237
IMGT
EMBL AC026770 AC090971 AF177169 AK293823 BC064961
GenPept AAF31668 AAH64961 BAG57227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca