Version 5.4
Homo sapiens Gene: TMOD2
Summary
InnateDB Gene IDBG-12237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMOD2
Gene Name tropomodulin 2 (neuronal)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128872
Encoded Proteins
IDBP-12239
tropomodulin 2 (neuronal)
IDBP-372859
tropomodulin 2 (neuronal)
IDBP-588907
tropomodulin 2 (neuronal)
IDBP-597144
tropomodulin 2 (neuronal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:51751561-51816368
Strand Forward strand
Band q21.2
Transcripts
ENST00000249700 ENSP00000249700
ENST00000435126 ENSP00000404590
ENST00000539962 ENSP00000437743
ENST00000560576
ENST00000561300
ENST00000561407 ENSP00000453524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 7 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
GO:0007270 neuron-neuron synaptic transmission
GO:0007399 nervous system development
GO:0007611 learning or memory
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0051694 pointed-end actin filament capping
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030426 growth cone
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032186
View Gene Order
ENSBTAG00000014011
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513734 Hs.666293 Hs.667162 Hs.722897
RefSeq NM_001142885 NM_014548
HUGO
OMIM
CCDS CCDS10144 CCDS45260
HPRD 04237
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca