Version 5.4
Homo sapiens Protein: SLC38A1
Summary
InnateDB Protein IDBP-373078.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC38A1
Protein Name solute carrier family 38, member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000398142
InnateDB Gene IDBG-28524 (SLC38A1)
Protein Structure
UniProt Annotation
Function Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO:0000269PubMed:10891391}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15054072}; Multi-pass membrane protein {ECO:0000269PubMed:15054072}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis. {ECO:0000269PubMed:10891391, ECO:0000269PubMed:12388062, ECO:0000269PubMed:15054072, ECO:0000269PubMed:16148032}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005283 sodium:amino acid symporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
GO:0007268 synaptic transmission
GO:0015804 neutral amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR013057 Amino acid transporter, transmembrane
PFAM PF01490
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2H9
PhosphoSite PhosphoSite-Q9H2H9
TrEMBL Q8NCD8
UniProt Splice Variant
Entrez Gene 81539
UniGene Hs.719858
RefSeq NP_001265316
HUGO HGNC:13447
OMIM 608490
CCDS CCDS41774
HPRD 12245
IMGT
EMBL AC016254 AC025031 AF247166 AF271070 AK027825 AK074758 AK074797 AK074949 BC010620 CH471111
GenPept AAG39354 AAG44546 AAH10620 BAB55394 BAC11186 BAC11215 BAC11310 EAW57895 EAW57896 EAW57897 EAW57898 EAW57899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca