InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRSF7

Summary

InnateDB Protein

IDBP-373104.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF7

Protein Name

serine/arginine-rich splicing factor 7

Synonyms

9G8; AAG3; SFRS7;

Species

Homo sapiens

Ensembl Protein

ENSP00000402544

InnateDB Gene

IDBG-46703 (SRSF7)

Protein Structure

UniProt Annotation

Function

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269PubMed:11336712, ECO:0000269PubMed:12667464, ECO:0000269PubMed:15009664, ECO:0000269PubMed:18364396}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11336712}. Cytoplasm {ECO:0000269PubMed:11336712}.

Disease Associations

Tissue Specificity

Brain, liver, kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	103 [view]
Protein-Protein	101 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0048025	negative regulation of mRNA splicing, via spliceosome