Version 5.4
Homo sapiens Gene: SRSF7
Summary
InnateDB Gene IDBG-46703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF7
Gene Name serine/arginine-rich splicing factor 7
Synonyms 9G8; AAG3; SFRS7
Species Homo sapiens
Ensembl Gene ENSG00000115875
Encoded Proteins
IDBP-46707
serine/arginine-rich splicing factor 7
IDBP-293947
serine/arginine-rich splicing factor 7
IDBP-373076
serine/arginine-rich splicing factor 7
IDBP-373079
serine/arginine-rich splicing factor 7
IDBP-373083
serine/arginine-rich splicing factor 7
IDBP-373091
serine/arginine-rich splicing factor 7
IDBP-373096
serine/arginine-rich splicing factor 7
IDBP-373101
serine/arginine-rich splicing factor 7
IDBP-373104
serine/arginine-rich splicing factor 7
IDBP-373107
serine/arginine-rich splicing factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38743599-38751494
Strand Reverse strand
Band p22.1
Transcripts
ENST00000313117 ENSP00000325905
ENST00000409276 ENSP00000386806
ENST00000425778 ENSP00000400246
ENST00000425941 ENSP00000416516
ENST00000452806 ENSP00000392300
ENST00000432873 ENSP00000401202
ENST00000431066 ENSP00000398159
ENST00000446327 ENSP00000402264
ENST00000443213 ENSP00000402544
ENST00000415527 ENSP00000408868
ENST00000477635
ENST00000487773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 103 [view]
Protein-Protein 101 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024097
View Gene Order
ENSBTAG00000014891
Not yet available
Pathways
NETPATH
REACTOME
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.309090 Hs.602930 Hs.711623
RefSeq NM_001031684 NM_001195446 XM_005264484 XM_005264485 XM_005264486
HUGO
OMIM
CCDS CCDS33183 CCDS56115
HPRD 08991
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca