Version 5.4
Homo sapiens Protein: HECW1
Summary
InnateDB Protein IDBP-373106.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HECW1
Protein Name HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms NEDL1;
Species Homo sapiens
Ensembl Protein ENSP00000407774
InnateDB Gene IDBG-13662 (HECW1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000569 HECT
IPR001202 WW domain
PFAM PF00168
PF00632
PF00397
PRINTS PR00360
PIRSF
SMART SM00239
SM00119
SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76N89
PhosphoSite PhosphoSite-Q76N89
TrEMBL
UniProt Splice Variant
Entrez Gene 23072
UniGene Hs.733552
RefSeq NP_001273988
HUGO HGNC:22195
OMIM 610384
CCDS CCDS69286
HPRD 11385
IMGT
EMBL AB002320 AB048365 AC004455 AC004692 AC005537 AC006365 AC011738 AK294918 BC151227
GenPept AAI51228 BAA20780 BAB13352 BAG58003

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca