Homo sapiens Gene: HECW1
Summary
InnateDB Gene IDBG-13662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HECW1
Gene Name HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms NEDL1
Species Homo sapiens
Ensembl Gene ENSG00000002746
Encoded Proteins
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:43112599-43566001
Strand Forward strand
Band p14.1
Transcripts
ENST00000395891 ENSP00000379228
ENST00000453890 ENSP00000407774
ENST00000429529 ENSP00000413336
ENST00000490954
ENST00000492310
ENST00000471527
ENST00000493057
ENST00000464944
ENST00000481031
ENST00000471043
ENST00000461842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
degradation of DVL pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.164453 Hs.733552
RefSeq NM_001287059 NM_015052 XM_005249665 XM_006715670 XM_006715671 XM_006715672 XM_006715673
HUGO
OMIM
CCDS CCDS5469 CCDS69286
HPRD 11385
IMGT
EMBL
GenPept
RNA Seq Atlas