InnateDB Protein
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IDBP-373146.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LIN54
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Protein Name
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lin-54 homolog (C. elegans)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000407139
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InnateDB Gene
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IDBG-27546 (LIN54)
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Protein Structure
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Function |
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005172
CRC domain
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PFAM |
PF03638
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6MZP7
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PhosphoSite |
PhosphoSite-Q6MZP7
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TrEMBL |
Q7Z3G2
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UniProt Splice Variant |
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Entrez Gene |
132660
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UniGene |
Hs.96952
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RefSeq |
NP_001275926
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HUGO |
HGNC:25397
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OMIM |
613367
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CCDS |
CCDS47089
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HPRD |
13218
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IMGT |
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EMBL |
AB111889
AC021105
AK292769
BC109277
BC109278
BX537919
BX640657
BX640966
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GenPept |
AAI09278
AAI09279
BAC98377
BAF85458
CAD97902
CAE45799
CAE45981
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