InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR98

Summary

InnateDB Protein

IDBP-373298.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR98

Protein Name

G protein-coupled receptor 98

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000392618

InnateDB Gene

IDBG-33218 (GPR98)

Protein Structure

UniProt Annotation

Function

Receptor that may have an important role in the development of the central nervous system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Usher syndrome 2C (USH2C) [MIM:605472]: USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. {ECO:0000269PubMed:14740321, ECO:0000269PubMed:22147658}. Note=The disease is caused by mutations affecting the gene represented in this entry.Febrile seizures, familial, 4 (FEB4) [MIM:604352]: Seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at low levels in adult tissues. {ECO:0000269PubMed:10976914}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007154	cell communication
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007399	nervous system development
GO:0007605	sensory perception of sound
GO:0016337	single organismal cell-cell adhesion
GO:0045494	photoreceptor cell maintenance
GO:0048496	maintenance of organ identity
GO:0050877	neurological system process
GO:0050953	sensory perception of light stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome