InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH17

Summary

InnateDB Protein

IDBP-373699.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH17

Protein Name

cadherin 17, LI cadherin (liver-intestine)

Synonyms

CDH16; HPT-1; HPT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000401468

InnateDB Gene

IDBG-28802 (CDH17)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269PubMed:8153632}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. {ECO:0000269PubMed:8153632}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0005509	calcium ion binding

Biological Process

GO:0006810	transport
GO:0006857	oligopeptide transport
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0035672	oligopeptide transmembrane transport