InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPF

Summary

InnateDB Protein

IDBP-373736.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPF

Protein Name

heterogeneous nuclear ribonucleoprotein F

Synonyms

HNRPF; mcs94-1; OK/SW-cl.23;

Species

Homo sapiens

Ensembl Protein

ENSP00000400433

InnateDB Gene

IDBG-71348 (HNRNPF)

Protein Structure

UniProt Annotation

Function

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269PubMed:20526337}.

Subcellular Localization

Nucleus, nucleoplasm.

Disease Associations

Tissue Specificity

Expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	149 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding