InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HNRNPF

Summary

InnateDB Gene

IDBG-71348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPF

Gene Name

heterogeneous nuclear ribonucleoprotein F

Synonyms

HNRPF; mcs94-1; OK/SW-cl.23

Species

Homo sapiens

Ensembl Gene

ENSG00000169813

Encoded Proteins

IDBP-71350

heterogeneous nuclear ribonucleoprotein F

IDBP-71352

heterogeneous nuclear ribonucleoprotein F

IDBP-71354

heterogeneous nuclear ribonucleoprotein F

IDBP-373736

heterogeneous nuclear ribonucleoprotein F

IDBP-584291

heterogeneous nuclear ribonucleoprotein F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:43385617-43409166

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000337970	ENSP00000338477
ENST00000356053	ENSP00000348345
ENST00000357065	ENSP00000349573
ENST00000443950	ENSP00000400433
ENST00000477108
ENST00000498176
ENST00000544000	ENSP00000438061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	149 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0043484	regulation of RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042079

View Gene Order

ENSBTAG00000008853

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P52597

TrEMBL

A0A024R7T3 B4DKS8 Q8NI96

UniProt Splice Variant

Entrez Gene

3185

UniGene

Hs.608733 Hs.808

RefSeq

NM_001098207 NM_001098204 NM_001098205 NM_001098206 NM_001098208 NM_004966

HUGO

HGNC:5039

OMIM

601037

CCDS

CCDS7204

HPRD

03023

IMGT

EMBL

AB062287 AK001364 AK296696 AL512654 BC001432 BC004254 BC015580 BC016736 BC106008 CH471160 L28010

GenPept

AAC37584 AAH01432 AAH04254 AAH15580 AAH16736 AAI06009 BAB93470 BAG50896 BAG59290 CAI17066 EAW86595 EAW86596 EAW86597 EAW86598 EAW86599

RNA Seq Atlas

3185