Version 5.4
Homo sapiens Protein: MARCH8
Summary
InnateDB Protein IDBP-373989.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH8
Protein Name membrane-associated ring finger (C3HC4) 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000411848
InnateDB Gene IDBG-71943 (MARCH8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042289 MHC class II protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0016567 protein ubiquitination
GO:0045347 negative regulation of MHC class II biosynthetic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF12906
PF00097
PRINTS
PIRSF
SMART SM00184
SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H0Y7C6
UniProt Splice Variant
Entrez Gene 220972
UniGene Hs.499489
RefSeq NP_001269795
HUGO HGNC:23356
OMIM 613335
CCDS CCDS60519
HPRD 17466
IMGT
EMBL AL445201 AL512595 AL731567 CH471160
GenPept EAW86647 EAW86648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca