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InnateDB Protein
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IDBP-373999.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MARCH8
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Protein Name
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membrane-associated ring finger (C3HC4) 8
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000396678
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InnateDB Gene
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IDBG-71943 (MARCH8)
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Protein Structure
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| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. {ECO:0000269PubMed:12582153, ECO:0000269PubMed:14722266, ECO:0000269PubMed:18389477, ECO:0000269PubMed:19117940, ECO:0000269PubMed:19566897}.
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| Subcellular Localization |
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
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| Disease Associations |
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| Tissue Specificity |
Broadly expressed. Present in immature dendritic cells (at protein level). {ECO:0000269PubMed:12582153, ECO:0000269PubMed:14722266}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
10
[view]
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| Protein-Protein |
10
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q5T0T0
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
220972
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| UniGene |
Hs.499489
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| RefSeq |
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| HUGO |
HGNC:23356
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| OMIM |
613335
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| CCDS |
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| HPRD |
17466
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4