InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHF20

Summary

InnateDB Protein

IDBP-374046.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHF20

Protein Name

PHD finger protein 20

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410373

InnateDB Gene

IDBG-71671 (PHF20)

Protein Structure

UniProt Annotation

Function

Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269PubMed:20018852, ECO:0000269PubMed:22864287}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20018852}.

Disease Associations

Tissue Specificity

Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues. {ECO:0000269PubMed:12097419}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046872	metal ion binding
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation