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InnateDB Protein
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IDBP-374061.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MCF2L
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Protein Name
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MCF.2 cell line derived transforming sequence-like
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Synonyms
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ARHGEF14; DBS; OST;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000395707
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InnateDB Gene
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IDBG-52007 (MCF2L)
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Protein Structure
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| Function |
Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. {ECO:0000250, ECO:0000269PubMed:15157669}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
16
[view]
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| Protein-Protein |
16
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-O15068
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| TrEMBL |
X6RE72
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| UniProt Splice Variant |
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| Entrez Gene |
23263
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| UniGene |
Hs.729031
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| RefSeq |
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| HUGO |
HGNC:14576
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| OMIM |
609499
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL137002
AL162454
AL356740
AL596093
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| GenPept |
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Version 5.4