Version 5.4
Homo sapiens Gene: MCF2L
Summary
InnateDB Gene IDBG-52007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCF2L
Gene Name MCF.2 cell line derived transforming sequence-like
Synonyms ARHGEF14; DBS; OST
Species Homo sapiens
Ensembl Gene ENSG00000126217
Encoded Proteins
IDBP-52009
MCF.2 cell line derived transforming sequence-like
IDBP-52011
MCF.2 cell line derived transforming sequence-like
IDBP-52015
MCF.2 cell line derived transforming sequence-like
IDBP-52021
MCF.2 cell line derived transforming sequence-like
IDBP-236243
MCF.2 cell line derived transforming sequence-like
IDBP-236245
MCF.2 cell line derived transforming sequence-like
IDBP-236247
MCF.2 cell line derived transforming sequence-like
IDBP-236249
MCF.2 cell line derived transforming sequence-like
IDBP-236251
MCF.2 cell line derived transforming sequence-like
IDBP-293475
MCF.2 cell line derived transforming sequence-like
IDBP-374048
MCF.2 cell line derived transforming sequence-like
IDBP-374059
MCF.2 cell line derived transforming sequence-like
IDBP-374061
MCF.2 cell line derived transforming sequence-like
IDBP-374124
MCF.2 cell line derived transforming sequence-like
IDBP-374126
MCF.2 cell line derived transforming sequence-like
IDBP-374128
MCF.2 cell line derived transforming sequence-like
IDBP-374130
MCF.2 cell line derived transforming sequence-like
IDBP-374133
MCF.2 cell line derived transforming sequence-like
IDBP-374136
MCF.2 cell line derived transforming sequence-like
IDBP-704440
IDBP-704452
IDBP-586035
MCF.2 cell line derived transforming sequence-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:112894378-113099739
Strand Forward strand
Band q34
Transcripts
ENST00000375608 ENSP00000364758
ENST00000375604 ENSP00000364754
ENST00000375597 ENSP00000364747
ENST00000261963 ENSP00000261963
ENST00000397036 ENSP00000380230
ENST00000397030 ENSP00000380225
ENST00000397024 ENSP00000380219
ENST00000397021 ENSP00000380216
ENST00000397017 ENSP00000380212
ENST00000409954 ENSP00000386551
ENST00000442625 ENSP00000398383
ENST00000421756 ENSP00000397285
ENST00000433807 ENSP00000395707
ENST00000423251 ENSP00000405996
ENST00000413354 ENSP00000407392
ENST00000453297 ENSP00000392953
ENST00000439475 ENSP00000411315
ENST00000420013 ENSP00000404422
ENST00000441756 ENSP00000395978
ENST00000486210
ENST00000486806 ENSP00000471913
ENST00000473345 ENSP00000473071
ENST00000480321
ENST00000469558
ENST00000494043
ENST00000464800
ENST00000475524
ENST00000487354
ENST00000491028
ENST00000469415
ENST00000488765
ENST00000535094 ENSP00000440374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031442
View Gene Order
ENSBTAG00000017289
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.135835 Hs.170422 Hs.614341 Hs.672223 Hs.729031
RefSeq NM_001112732 NM_024979 XM_005268308 XM_005268310 XM_005268314 XM_005268315 XM_005268316
HUGO
OMIM
CCDS CCDS45070 CCDS9527
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca