InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FER

Summary

InnateDB Protein

IDBP-374537.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FER

Protein Name

fer (fps/fes related) tyrosine kinase

Synonyms

FerT; Pe1Fe10; Pe1Fe13; Pe1Fe3; Pe1Fe6; PPP1R74; TYK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000394297

InnateDB Gene

IDBG-36195 (FER)

Protein Structure

UniProt Annotation

Function

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. {ECO:0000269PubMed:12972546, ECO:0000269PubMed:14517306, ECO:0000269PubMed:19147545, ECO:0000269PubMed:19339212, ECO:0000269PubMed:19738202, ECO:0000269PubMed:20111072, ECO:0000269PubMed:21518868, ECO:0000269PubMed:22223638, ECO:0000269PubMed:7623846, ECO:0000269PubMed:9722593}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts.

Disease Associations

Tissue Specificity

Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. {ECO:0000269PubMed:18985748, ECO:0000269PubMed:2156206, ECO:0000269PubMed:22223638}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001932	regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010591	regulation of lamellipodium assembly
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0031532	actin cytoskeleton reorganization
GO:0032496	response to lipopolysaccharide
GO:0032869	cellular response to insulin stimulus
GO:0033007	negative regulation of mast cell activation involved in immune response
GO:0034446	substrate adhesion-dependent cell spreading
GO:0034614	cellular response to reactive oxygen species
GO:0035426	extracellular matrix-cell signaling
GO:0035556	intracellular signal transduction
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0036119	response to platelet-derived growth factor stimulus
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038109	Kit signaling pathway
GO:0042058	regulation of epidermal growth factor receptor signaling pathway
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0044331	cell-cell adhesion mediated by cadherin
GO:0046777	protein autophosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050904	diapedesis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070102	interleukin-6-mediated signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001060 FCH domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016250 Tyrosine-protein kinase, Fes/Fps type
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF00611
PF07714

PRINTS

PR00401
PR00109

PIRSF

PIRSF000632

SMART

SM00252
SM00055
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References