InnateDB Protein
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IDBP-374560.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDLIM5
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Protein Name
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PDZ and LIM domain 5
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Synonyms
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ENH; ENH1; LIM;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398469
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InnateDB Gene
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IDBG-30475 (PDLIM5)
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Protein Structure
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Function |
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Detected both at presynaptic and postsynaptic sites. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression. {ECO:0000269PubMed:10429367, ECO:0000269PubMed:16044170, ECO:0000269PubMed:16213469}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q96HC4
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PhosphoSite |
PhosphoSite-Q96HC4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10611
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UniGene |
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RefSeq |
NP_001243354
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HUGO |
HGNC:17468
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OMIM |
605904
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CCDS |
CCDS75166
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HPRD |
05799
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IMGT |
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EMBL |
AC093778
AC108067
AC109925
AF061258
AK291624
AK291898
AL833438
AY345240
AY598328
BC008741
BC017902
BT007328
CH471057
CR610626
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GenPept |
AAC15767
AAH08741
AAH17902
AAP35992
AAR09142
AAT06739
BAF84313
BAF84587
EAX06054
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